High-impact FN1 mutation decreases chondrogenic potential and affects cartilage deposition via decreased binding to collagen type II

Osteoarthritis is the most prevalent joint disease worldwide, yet progress in development of effective disease-modifying treatments is slow because of lack of insight into the underlying disease pathways. Therefore, we aimed to identify the causal pathogenic mutation in an early-onset osteoarthritis...

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Detalles Bibliográficos
Autores principales: van Hoolwerff, Marcella, Rodríguez Ruiz, Alejandro, Bouma, Marga, Suchiman, H. Eka D., Koning, Roman I., Jost, Carolina R., Mulder, Aat A., Freund, Christian, Guilak, Farshid, Ramos, Yolande F. M., Meulenbelt, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570604/
https://www.ncbi.nlm.nih.gov/pubmed/34739320
http://dx.doi.org/10.1126/sciadv.abg8583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570604/
https://www.ncbi.nlm.nih.gov/pubmed/34739320
http://dx.doi.org/10.1126/sciadv.abg8583

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