PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway

Brain tumor–initiating cells (BTICs) drive glioblastoma growth through not fully understood mechanisms. Here, we found that about 8% of cells within the human glioblastoma microenvironment coexpress programmed cell death 1 (PD-1) and BTIC marker. Gain- or loss-of-function studies revealed that tumor...

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Detalles Bibliográficos
Autores principales: Mirzaei, Reza, Gordon, Ashley, Zemp, Franz J., Kumar, Mehul, Sarkar, Susobhan, Luchman, H. Artee, Bellail, Anita C., Hao, Chunhai, Mahoney, Douglas J., Dunn, Jeff F., Bose, Pinaki, Yong, V. Wee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570610/
https://www.ncbi.nlm.nih.gov/pubmed/34739319
http://dx.doi.org/10.1126/sciadv.abh2148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570610/
https://www.ncbi.nlm.nih.gov/pubmed/34739319
http://dx.doi.org/10.1126/sciadv.abh2148

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