IFN-γ mediates Paneth cell death via suppression of mTOR

Paneth cells constitutively produce antimicrobial peptides and growth factors that allow for intestinal homeostasis, host protection, and intestinal stem cell replication. Paneth cells rely heavily on the glycolytic metabolic program, which is in part controlled by the kinase complex Mechanistic tar...

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Detalles Bibliográficos
Autores principales: Araujo, Alessandra, Safronova, Alexandra, Burger, Elise, López-Yglesias, Américo, Giri, Shilpi, Camanzo, Ellie T, Martin, Andrew T, Grivennikov, Sergei, Yarovinsky, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570691/
https://www.ncbi.nlm.nih.gov/pubmed/34633285
http://dx.doi.org/10.7554/eLife.60478

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570691/
https://www.ncbi.nlm.nih.gov/pubmed/34633285
http://dx.doi.org/10.7554/eLife.60478

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