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A Plausible Metal-Free Ancestral Analogue of the Krebs Cycle Composed Entirely of α-Ketoacids.

Efforts to decipher the prebiotic roots of metabolic pathways have focused on recapitulating modern biological transformations, with metals typically serving in place of cofactors and enzymes. Here, we show that the reaction of glyoxylate with pyruvate under mild aqueous conditions produces a series...

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Detalles Bibliográficos
Autores principales: Stubbs, R. Trent, Yadav, Mahipal, Krishnamurthy, Ramanarayanan, Springsteen, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570912/
https://www.ncbi.nlm.nih.gov/pubmed/33046840
http://dx.doi.org/10.1038/s41557-020-00560-7