Structural and thermodynamical insights into the binding and inhibition of FIH-1 by the N-terminal disordered region of Mint3

Mint3 is known to enhance aerobic ATP production, known as the Warburg effect, by binding to FIH-1. Since this effect is considered to be beneficial for cancer cells, the interaction is a promising target for cancer therapy. However, previous research has suggested that the interacting region of Min...

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Detalles Bibliográficos
Autores principales: Ten, Tensho, Nagatoishi, Satoru, Maeda, Ryo, Hoshino, Masaru, Nakayama, Yoshiaki, Seiki, Motoharu, Sakamoto, Takeharu, Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571082/
https://www.ncbi.nlm.nih.gov/pubmed/34655613
http://dx.doi.org/10.1016/j.jbc.2021.101304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571082/
https://www.ncbi.nlm.nih.gov/pubmed/34655613
http://dx.doi.org/10.1016/j.jbc.2021.101304

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