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Structural and thermodynamical insights into the binding and inhibition of FIH-1 by the N-terminal disordered region of Mint3
Mint3 is known to enhance aerobic ATP production, known as the Warburg effect, by binding to FIH-1. Since this effect is considered to be beneficial for cancer cells, the interaction is a promising target for cancer therapy. However, previous research has suggested that the interacting region of Min...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571082/ https://www.ncbi.nlm.nih.gov/pubmed/34655613 http://dx.doi.org/10.1016/j.jbc.2021.101304 |