Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia

Acute myeloid and lymphoid leukemias often harbor chromosomal translocations involving the KMT2A gene, encoding the KMT2A lysine methyltransferase (also known as mixed-lineage leukemia-1), and produce in-frame fusions of KMT2A to other chromatin-regulatory proteins. Here we map fusion-specific targe...

Descripción completa

Detalles Bibliográficos
Autores principales: Janssens, Derek H., Meers, Michael P., Wu, Steven J., Babaeva, Ekaterina, Meshinchi, Soheil, Sarthy, Jay F., Ahmad, Kami, Henikoff, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571097/
https://www.ncbi.nlm.nih.gov/pubmed/34663924
http://dx.doi.org/10.1038/s41588-021-00941-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571097/
https://www.ncbi.nlm.nih.gov/pubmed/34663924
http://dx.doi.org/10.1038/s41588-021-00941-9

Ejemplares similares