IL-7 coupled with IL-12 increases intratumoral T cell clonality, leading to complete regression of non-immunogenic tumors

Immune checkpoint inhibitors against PD-1, PD-L1 and CTLA-4 have altered the treatment paradigm for various types of cancers in the past decade. However, they offer clinical benefits to only a subset of patients. Evaluation and identification of an appropriate therapeutic approach to improve intratu...

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Detalles Bibliográficos
Autores principales: Tasaki, Mamoru, Yamashita, Midori, Arai, Yukinori, Nakamura, Takafumi, Nakao, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571137/
https://www.ncbi.nlm.nih.gov/pubmed/33909103
http://dx.doi.org/10.1007/s00262-021-02947-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571137/
https://www.ncbi.nlm.nih.gov/pubmed/33909103
http://dx.doi.org/10.1007/s00262-021-02947-y

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