Combined vaccine-immune-checkpoint inhibition constitutes a promising strategy for treatment of dMMR tumors

BACKGROUND: Mlh1-knock-out-driven mismatch-repair-deficient (dMMR) tumors can be targeted immunologically. By applying therapeutic tumor vaccination, tumor growth is delayed but escape mechanisms evolve, including upregulation of immune-checkpoint molecules (LAG-3, PD-L1). To counteract immune escap...

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Detalles Bibliográficos
Autores principales: Salewski, Inken, Kuntoff, Steffen, Kuemmel, Andreas, Feldtmann, Rico, Felix, Stephan B., Henze, Larissa, Junghanss, Christian, Maletzki, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571220/
https://www.ncbi.nlm.nih.gov/pubmed/33870463
http://dx.doi.org/10.1007/s00262-021-02933-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571220/
https://www.ncbi.nlm.nih.gov/pubmed/33870463
http://dx.doi.org/10.1007/s00262-021-02933-4

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