Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM

Systemic AL amyloidosis is a rare disease that is caused by the misfolding of immunoglobulin light chains (LCs). Potential drivers of amyloid formation in this disease are post-translational modifications (PTMs) and the mutational changes that are inserted into the LCs by somatic hypermutation. Here...

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Detalles Bibliográficos
Autores principales: Radamaker, Lynn, Karimi-Farsijani, Sara, Andreotti, Giada, Baur, Julian, Neumann, Matthias, Schreiner, Sarah, Berghaus, Natalie, Motika, Raoul, Haupt, Christian, Walther, Paul, Schmidt, Volker, Huhn, Stefanie, Hegenbart, Ute, Schönland, Stefan O., Wiese, Sebastian, Read, Clarissa, Schmidt, Matthias, Fändrich, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571268/
https://www.ncbi.nlm.nih.gov/pubmed/34741031
http://dx.doi.org/10.1038/s41467-021-26553-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571268/
https://www.ncbi.nlm.nih.gov/pubmed/34741031
http://dx.doi.org/10.1038/s41467-021-26553-9

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