Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets

Remdesivir is an antiviral approved for COVID-19 treatment, but its wider use is limited by intravenous delivery. An orally bioavailable remdesivir analog may boost therapeutic benefit by facilitating early administration to non-hospitalized patients. This study characterizes the anti-SARS-CoV-2 eff...

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Detalles Bibliográficos
Autores principales: Cox, Robert M., Wolf, Josef D., Lieber, Carolin M., Sourimant, Julien, Lin, Michelle J., Babusis, Darius, DuPont, Venice, Chan, Julie, Barrett, Kim T., Lye, Diane, Kalla, Rao, Chun, Kwon, Mackman, Richard L., Ye, Chengjin, Cihlar, Tomas, Martinez-Sobrido, Luis, Greninger, Alexander L., Bilello, John P., Plemper, Richard K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571282/
https://www.ncbi.nlm.nih.gov/pubmed/34741049
http://dx.doi.org/10.1038/s41467-021-26760-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571282/
https://www.ncbi.nlm.nih.gov/pubmed/34741049
http://dx.doi.org/10.1038/s41467-021-26760-4

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