Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs

To understand how RNA dynamics is regulated and connected to its function, we investigate the folding, conformational dynamics and robustness of Xrn1 resistance of a set of flaviviral xrRNAs using SAXS, smFRET and in vitro enzymatic assays. Flaviviral xrRNAs form discrete ring-like 3D structures, in...

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Detalles Bibliográficos
Autores principales: Niu, Xiaolin, Sun, Ruirui, Chen, Zhifeng, Yao, Yirong, Zuo, Xiaobing, Chen, Chunlai, Fang, Xianyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571300/
https://www.ncbi.nlm.nih.gov/pubmed/34741027
http://dx.doi.org/10.1038/s41467-021-26616-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571300/
https://www.ncbi.nlm.nih.gov/pubmed/34741027
http://dx.doi.org/10.1038/s41467-021-26616-x

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