Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope

High-affinity MHC I-peptide interactions are considered essential for immunogenicity. However, some neo-epitopes with low affinity for MHC I have been reported to elicit CD8 T cell dependent tumor rejection in immunization-challenge studies. Here we show in a mouse model that a neo-epitope that poor...

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Detalles Bibliográficos
Autores principales: Ebrahimi-Nik, Hakimeh, Moussa, Marmar, Englander, Ryan P., Singhaviranon, Summit, Michaux, Justine, Pak, HuiSong, Miyadera, Hiroko, Corwin, William L., Keller, Grant L. J., Hagymasi, Adam T., Shcheglova, Tatiana V., Coukos, George, Baker, Brian M., Mandoiu, Ion I., Bassani-Sternberg, Michal, Srivastava, Pramod K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571378/
https://www.ncbi.nlm.nih.gov/pubmed/34741035
http://dx.doi.org/10.1038/s41467-021-26646-5

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