Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope
High-affinity MHC I-peptide interactions are considered essential for immunogenicity. However, some neo-epitopes with low affinity for MHC I have been reported to elicit CD8 T cell dependent tumor rejection in immunization-challenge studies. Here we show in a mouse model that a neo-epitope that poor...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571378/ https://www.ncbi.nlm.nih.gov/pubmed/34741035 http://dx.doi.org/10.1038/s41467-021-26646-5 |