Potentiating antibiotic efficacy via perturbation of non-essential gene expression

Proliferation of multidrug-resistant (MDR) bacteria poses a threat to human health, requiring new strategies. Here we propose using fitness neutral gene expression perturbations to potentiate antibiotics. We systematically explored 270 gene knockout-antibiotic combinations in Escherichia coli, ident...

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Detalles Bibliográficos
Autores principales: Otoupal, Peter B., Eller, Kristen A., Erickson, Keesha E., Campos, Jocelyn, Aunins, Thomas R., Chatterjee, Anushree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571399/
https://www.ncbi.nlm.nih.gov/pubmed/34741116
http://dx.doi.org/10.1038/s42003-021-02783-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571399/
https://www.ncbi.nlm.nih.gov/pubmed/34741116
http://dx.doi.org/10.1038/s42003-021-02783-x

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