Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation

VCP/p97 is an evolutionarily conserved AAA+ ATPase important for cellular homeostasis. Previous studies suggest that VCP predominantly exists as a homohexamer. Here, we performed structural and biochemical characterization of VCP dodecamer, an understudied state of VCP. The structure revealed an apo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Guimei, Bai, Yunpeng, Li, Kunpeng, Amarasinghe, Ovini, Jiang, Wen, Zhang, Zhong-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571493/
https://www.ncbi.nlm.nih.gov/pubmed/34765927
http://dx.doi.org/10.1016/j.isci.2021.103310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571493/
https://www.ncbi.nlm.nih.gov/pubmed/34765927
http://dx.doi.org/10.1016/j.isci.2021.103310

Ejemplares similares