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Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation
VCP/p97 is an evolutionarily conserved AAA+ ATPase important for cellular homeostasis. Previous studies suggest that VCP predominantly exists as a homohexamer. Here, we performed structural and biochemical characterization of VCP dodecamer, an understudied state of VCP. The structure revealed an apo...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571493/ https://www.ncbi.nlm.nih.gov/pubmed/34765927 http://dx.doi.org/10.1016/j.isci.2021.103310 |