Inclusion of a degron reduces levelsof undesired inteins after AAV-mediated proteintrans-splicing in the retina

Split intein-mediated protein trans-splicing expands AAV transfer capacity, thus overcoming the limited AAV cargo. However, non-mammalian inteins persist as trans-splicing by-products, and this could raise safety concerns for AAV intein clinical applications. In this study, we tested the ability of...

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Detalles Bibliográficos
Autores principales: Tornabene, Patrizia, Trapani, Ivana, Centrulo, Miriam, Marrocco, Elena, Minopoli, Renato, Lupo, Mariangela, Iodice, Carolina, Gesualdo, Carlo, Simonelli, Francesca, Surace, Enrico M., Auricchio, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571531/
https://www.ncbi.nlm.nih.gov/pubmed/34786437
http://dx.doi.org/10.1016/j.omtm.2021.10.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571531/
https://www.ncbi.nlm.nih.gov/pubmed/34786437
http://dx.doi.org/10.1016/j.omtm.2021.10.004

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