Detection of glucose-derived d- and l-lactate in cancer cells by the use of a chiral NMR shift reagent

BACKGROUND: Excessive lactate production, a hallmark of cancer, is largely formed by the reduction of pyruvate via lactate dehydrogenase (LDH) to l-lactate. Although d-lactate can also be produced from glucose via the methylglyoxal pathway in small amounts, less is known about the amount of d-lactat...

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Detalles Bibliográficos
Autores principales: Suh, Eul Hyun, Geraldes, Carlos F. G. C., Chirayil, Sara, Faubert, Brandon, Ayala, Raul, DeBerardinis, Ralph J., Sherry, A. Dean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571830/
https://www.ncbi.nlm.nih.gov/pubmed/34742347
http://dx.doi.org/10.1186/s40170-021-00267-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571830/
https://www.ncbi.nlm.nih.gov/pubmed/34742347
http://dx.doi.org/10.1186/s40170-021-00267-4

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