ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling

Sortilin is a neuronal receptor for apolipoprotein E (apoE). Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain. This neuroprotective pathway works with the apoE3 varian...

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Detalles Bibliográficos
Autores principales: Asaro, Antonino, Sinha, Rishabhdev, Bakun, Magda, Kalnytska, Oleksandra, Carlo-Spiewok, Anne-Sophie, Rubel, Tymon, Rozeboom, Annemieke, Dadlez, Michal, Kaminska, Bozena, Aronica, Eleonora, Malik, Anna R., Willnow, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572006/
https://www.ncbi.nlm.nih.gov/pubmed/34557909
http://dx.doi.org/10.1242/jcs.258894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572006/
https://www.ncbi.nlm.nih.gov/pubmed/34557909
http://dx.doi.org/10.1242/jcs.258894

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