Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma

Genetic aberrations are present in the ATRX gene in older high-risk neuroblastoma (NB) patients with very poor clinical outcomes. Its loss-of-function (LoF) facilitates the alternative lengthening of telomeres (ALT) pathway in tumor cells and is strongly linked to replication stress (RS) and DNA dam...

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Detalles Bibliográficos
Autores principales: Akter, Jesmin, Katai, Yutaka, Sultana, Parvin, Takenobu, Hisanori, Haruta, Masayuki, Sugino, Ryuichi P., Mukae, Kyosuke, Satoh, Shunpei, Wada, Tomoko, Ohira, Miki, Ando, Kiyohiro, Kamijo, Takehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572175/
https://www.ncbi.nlm.nih.gov/pubmed/34743173
http://dx.doi.org/10.1038/s41389-021-00363-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572175/
https://www.ncbi.nlm.nih.gov/pubmed/34743173
http://dx.doi.org/10.1038/s41389-021-00363-6

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