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Loss of p53 suppresses replication stress-induced DNA damage in ATRX-deficient neuroblastoma
Genetic aberrations are present in the ATRX gene in older high-risk neuroblastoma (NB) patients with very poor clinical outcomes. Its loss-of-function (LoF) facilitates the alternative lengthening of telomeres (ALT) pathway in tumor cells and is strongly linked to replication stress (RS) and DNA dam...
Autores principales: | Akter, Jesmin, Katai, Yutaka, Sultana, Parvin, Takenobu, Hisanori, Haruta, Masayuki, Sugino, Ryuichi P., Mukae, Kyosuke, Satoh, Shunpei, Wada, Tomoko, Ohira, Miki, Ando, Kiyohiro, Kamijo, Takehiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572175/ https://www.ncbi.nlm.nih.gov/pubmed/34743173 http://dx.doi.org/10.1038/s41389-021-00363-6 |
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