DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils

How pathogenesis of inflammatory bowel disease (IBD) depends on the complex interplay of host genetics, microbiome and the immune system is not fully understood. Here, we showed that Downstream of Kinase 3 (DOK3), an adapter protein involved in immune signaling, confers protection of mice from dextr...

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Detalles Bibliográficos
Autores principales: Loh, Jia Tong, Lee, Koon-Guan, Lee, Alison P., Teo, Joey Kay Hui, Lim, Hsueh Lee, Kim, Susana Soo-Yeon, Tan, Andy Hee-Meng, Lam, Kong-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572282/
https://www.ncbi.nlm.nih.gov/pubmed/34743196
http://dx.doi.org/10.1038/s41419-021-04357-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572282/
https://www.ncbi.nlm.nih.gov/pubmed/34743196
http://dx.doi.org/10.1038/s41419-021-04357-5

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