Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods

Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. To mitigate the side effects of URAT1-targeted clinical agents such as benzbromarone, there is significant interes...

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Detalles Bibliográficos
Autores principales: Chen, Ying, You, Ruya, Wang, Ke, Wang, Yousheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572588/
https://www.ncbi.nlm.nih.gov/pubmed/34754317
http://dx.doi.org/10.1155/2021/5738900
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author Chen, Ying
You, Ruya
Wang, Ke
Wang, Yousheng
author_facet Chen, Ying
You, Ruya
Wang, Ke
Wang, Yousheng
author_sort Chen, Ying
collection PubMed
description Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. To mitigate the side effects of URAT1-targeted clinical agents such as benzbromarone, there is significant interest in discovering new URAT1 inhibitors and developing technology that can evaluate URAT1 inhibition. This review summarizes the methods for assay of URAT1 inhibition and the progress on the discovery of natural and synthetic URAT1 inhibitors in the past five years.
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spelling pubmed-85725882021-11-08 Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods Chen, Ying You, Ruya Wang, Ke Wang, Yousheng Evid Based Complement Alternat Med Review Article Human urate anion transporter 1 (hURAT1) is responsible for the reabsorption of uric acid in the proximal renal tubules and is a promising therapeutic target for treating hyperuricemia. To mitigate the side effects of URAT1-targeted clinical agents such as benzbromarone, there is significant interest in discovering new URAT1 inhibitors and developing technology that can evaluate URAT1 inhibition. This review summarizes the methods for assay of URAT1 inhibition and the progress on the discovery of natural and synthetic URAT1 inhibitors in the past five years. Hindawi 2021-10-31 /pmc/articles/PMC8572588/ /pubmed/34754317 http://dx.doi.org/10.1155/2021/5738900 Text en Copyright © 2021 Ying Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Ying
You, Ruya
Wang, Ke
Wang, Yousheng
Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title_full Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title_fullStr Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title_full_unstemmed Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title_short Recent Updates of Natural and Synthetic URAT1 Inhibitors and Novel Screening Methods
title_sort recent updates of natural and synthetic urat1 inhibitors and novel screening methods
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572588/
https://www.ncbi.nlm.nih.gov/pubmed/34754317
http://dx.doi.org/10.1155/2021/5738900
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