Cargando…

Apatinib inhibits the growth of small cell lung cancer via a mechanism mediated by VEGF, PI3K/Akt and Ki‐67/CD31

This study aimed to investigate the anti‐tumour effect of apatinib on extensive‐stage small cell lung cancer (SCLC) and elucidate the associated mechanisms. NCI‐H345 cells were selected as model cells because of high expression of vascular endothelial growth factor (VEGF), VEGF receptor 2 (VEGFR2) a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhong, Ning, Zhuang, Wei, Huang, Qian, Wang, Qiang, Jin, Wenjian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572765/ https://www.ncbi.nlm.nih.gov/pubmed/34590406 http://dx.doi.org/10.1111/jcmm.16926

Ejemplares similares

Combination of Cordycepin and Apatinib Synergistically Inhibits NSCLC Cells by Down-Regulating VEGF/PI3K/Akt Signaling Pathway
por: Liao, Xiaozhong, et al.
Publicado: (2020)

Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways
por: Song, Jifu, et al.
Publicado: (2021)

VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma
por: Park, Seongyeol, et al.
Publicado: (2016)

Immunohistochemical expression of p53, Ki67, α-SMA, CD44 and CD31 in different histological subtypes of basal cell carcinoma
por: Cojocaru, Anca, et al.
Publicado: (2022)

Ki67 and CD31 Differential Expression in Cutaneous T-Cell Lymphoma and Its Mimickers: Association with Clinicopathological Criteria and Disease Advancement
por: Zohdy, Marwa, et al.
Publicado: (2020)

Ki-67 gene expression
por: Uxa, Sigrid, et al.
Publicado: (2021)

Apatinib affect VEGF-mediated cell proliferation, migration, invasion via blocking VEGFR2/RAF/MEK/ERK and PI3K/AKT pathways in cholangiocarcinoma cell
por: Huang, Manping, et al.
Publicado: (2018)

To Ki or Not to Ki: Re-Evaluating the Use and Potentials of Ki-67 for T Cell Analysis
por: Di Rosa, Francesca, et al.
Publicado: (2021)

Prognostic Value of GPNMB, EGFR, p-PI3K, and Ki-67 in Patients with Esophageal Squamous Cell Carcinoma
por: Wang, Bo, et al.
Publicado: (2022)

Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma
por: Liao, Junbin, et al.
Publicado: (2019)

Correlationship between Ki67, VEGF, and p53 and Hepatocellular Carcinoma Recurrence in Liver Transplant Patients
por: Zhang, Xia, et al.
Publicado: (2021)

Expression of Markers Ki-67, Nestin, VEGF, CD34 and Apoptosis in Relatively Healthy Lung Tissue with Non-Changed and Metaplastic Bronchial Epithelium
por: Zarina, Kaiva Zile, et al.
Publicado: (2022)

Corrigendum: To Ki or Not to Ki: Re-Evaluating the Use and Potentials of Ki-67 for T Cell Analysis
por: Di Rosa, Francesca, et al.
Publicado: (2021)

Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway
por: Zhang, Hua, et al.
Publicado: (2018)

The intrinsically disorderly story of Ki-67
por: Remnant, Lucy, et al.
Publicado: (2021)

CD133 and Ki-67 expression is associated with gastrointestinal stromal tumor prognosis
por: LU, CANRONG, et al.
Publicado: (2013)

Ki‐67/CD3 ratio in the diagnosis of chronic inflammatory enteropathy in dogs
por: Karlovits, Sonja, et al.
Publicado: (2019)

Correlation and significance of COX-2, Ki67, VEGF and other immune indexes with the growth of malignant pulmonary nodules
por: Guo, Haoxin, et al.
Publicado: (2022)

Immunohistochemical expression of COX-2, Ki-67, Bcl-2, Bax, VEGF and CD105 according to histological grading in oral squamous cell carcinoma
por: Escobar, Enrico, et al.
Publicado: (2023)

Apatinib inhibits VEGF signaling and promotes apoptosis in intrahepatic cholangiocarcinoma
por: Peng, Hong, et al.
Publicado: (2016)

piNET–An Automated Proliferation Index Calculator Framework for Ki67 Breast Cancer Images
por: Geread, Rokshana Stephny, et al.
Publicado: (2020)

Proliferative activity in human breast cancer: Ki-67 automated evaluation and the influence of different Ki-67 equivalent antibodies
por: Fasanella, S, et al.
Publicado: (2011)

Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group
por: Nielsen, Torsten O, et al.
Publicado: (2020)

Expression and correlation of the Pi3k/Akt pathway and VEGF in oral submucous fibrosis
por: Lin, Yanan, et al.
Publicado: (2023)

Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma
por: Yu, Xiying, et al.
Publicado: (2020)

CAIX在NSCLC中的表达及其与VEGF和Ki67表达的相关性
Publicado: (2010)

Turnover of CD4(+) and CD8(+) T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen
por: Sachsenberg, Nicolas, et al.
Publicado: (1998)

Immunohistochemical expression of P53, Ki-67, and CD34 in psoriasis and psoriasiform dermatitis
por: Ramezani, Mazaher, et al.
Publicado: (2019)

Immunolocalization of Ki-67 in different periodontal conditions
por: Preethi, Penubolu Lakshmi, et al.
Publicado: (2014)

Comparative Study of Correlation between Angiogenesis Markers (CD31) and Ki67 Marker with Behavior of Aggressive and Nonaggressive Central Giant Cell Granuloma with Immunohistochemistry Technique
por: Razavi, Seyed Mohammad, et al.
Publicado: (2018)

Quantum Dots-Based Quantitative and In Situ Multiple Imaging on Ki67 and Cytokeratin to Improve Ki67 Assessment in Breast Cancer
por: Yuan, Jing Ping, et al.
Publicado: (2015)

ki67 nuclei detection and ki67-index estimation: a novel automatic approach based on human vision modeling
por: Barricelli, Barbara Rita, et al.
Publicado: (2019)

Independent Clinical Validation of the Automated Ki67 Scoring Guideline from the International Ki67 in Breast Cancer Working Group
por: Boyaci, Ceren, et al.
Publicado: (2021)

Low correlation between Ki67 assessed by qRT-PCR in Oncotype Dx score and Ki67 assessed by Immunohistochemistry
por: Selmani, Zohair, et al.
Publicado: (2022)

Ki-67 and breast cancer prognosis: does it matter if Ki-67 level is examined using preoperative biopsy or postoperative specimen?
por: Choi, Soon Bo, et al.
Publicado: (2022)

Dynamic chromosomal interactions and control of heterochromatin positioning by Ki‐67
por: van Schaik, Tom, et al.
Publicado: (2022)

Apatinib inhibits pancreatic cancer growth, migration and invasion through the PI3K/AKT and ERK1/2/MAPK pathways
por: Hu, Yuan, et al.
Publicado: (2021)

Decreasing expression of HIF-1α, VEGF-A, and Ki67 with efficacy of neoadjuvant therapy in locally advanced cervical cancer
por: Zhao, Ke, et al.
Publicado: (2023)

Apatinib Inhibits Cell Proliferation and Induces Autophagy in Human Papillary Thyroid Carcinoma via the PI3K/Akt/mTOR Signaling Pathway
por: Meng, Xiangrui, et al.
Publicado: (2020)

A comparative study between Ki67 positive versus Ki67 negative females with breast cancer: Cross sectional study
por: Bahaddin, Mowafak Masoud
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6ck8r2a16t2afr7abltn2lfi8j