Cargando…

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

BACKGROUND: The insulin/IGF-1 signaling pathway has a major role in the regulation of longevity both in Caenorhabditis elegans and mammalian species, i.e., reduced activity of this pathway extends lifespan, whereas increased activity accelerates the aging process. The insulin/IGF-1 pathway controls...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572812/ https://www.ncbi.nlm.nih.gov/pubmed/34476533 http://dx.doi.org/10.1007/s00011-021-01498-3

Ejemplares similares

Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin
por: Salminen, Antero, et al.
Publicado: (2022)

ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease
por: Salminen, Antero, et al.
Publicado: (2020)

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases
por: Salminen, Antero, et al.
Publicado: (2016)

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
por: Salminen, Antero, et al.
Publicado: (2013)

Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process
por: Salminen, Antero, et al.
Publicado: (2012)

AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging
por: Salminen, Antero, et al.
Publicado: (2019)

Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency
por: Salminen, Antero, et al.
Publicado: (2019)

Potential Role of Myeloid-Derived Suppressor Cells (MDSCs) in Age-Related Macular Degeneration (AMD)
por: Kauppinen, Anu, et al.
Publicado: (2020)

Inflammation and its role in age-related macular degeneration
por: Kauppinen, Anu, et al.
Publicado: (2016)

Inflammaging: disturbed interplay between autophagy and inflammasomes
por: Salminen, Antero, et al.
Publicado: (2012)

The role of immunosuppressive myofibroblasts in the aging process and age-related diseases
por: Salminen, Antero
Publicado: (2023)

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
por: Kaarniranta, Kai, et al.
Publicado: (2020)

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
por: Salminen, Antero, et al.
Publicado: (2009)

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology
por: Salminen, Antero, et al.
Publicado: (2008)

Immunosuppressive network promotes immunosenescence associated with aging and chronic inflammatory conditions
por: Salminen, Antero
Publicado: (2021)

Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
por: Kaarniranta, Kai, et al.
Publicado: (2013)

Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro
por: Jauhonen, Hanna-Mari, et al.
Publicado: (2011)

Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases
por: Salminen, Antero
Publicado: (2020)

The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells
por: Paimela, Tuomas, et al.
Publicado: (2012)

Clinical perspectives on the age-related increase of immunosuppressive activity
por: Salminen, Antero
Publicado: (2022)

Genetic Variability in DNA Repair Proteins in Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2012)

Mitochondrial and Nuclear DNA Damage and Repair in Age-Related Macular Degeneration
por: Blasiak, Janusz, et al.
Publicado: (2013)

The Regulation of NFE2L2 (NRF2) Signalling and Epithelial-to-Mesenchymal Transition in Age-Related Macular Degeneration Pathology
por: Hyttinen, Juha M. T., et al.
Publicado: (2019)

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
por: Salminen, Antero, et al.
Publicado: (2011)

Aryl hydrocarbon receptor (AhR) reveals evidence of antagonistic pleiotropy in the regulation of the aging process
por: Salminen, Antero
Publicado: (2022)

Differential Expression of Inflammasome-Related Genes in Induced Pluripotent Stem-Cell-Derived Retinal Pigment Epithelial Cells with or without History of Age-Related Macular Degeneration
por: Hytti, Maria, et al.
Publicado: (2021)

Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network
por: Partridge, Linda, et al.
Publicado: (2011)

The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
por: Kenyon, Cynthia
Publicado: (2011)

Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells
por: Sridevi Gurubaran, Iswariyaraja, et al.
Publicado: (2022)

Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells
por: Bhattarai, Niina, et al.
Publicado: (2021)

Influence of Hsp90 and HDAC Inhibition and Tubulin Acetylation on Perinuclear Protein Aggregation in Human Retinal Pigment Epithelial Cells
por: Ryhänen, Tuomas, et al.
Publicado: (2011)

Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegans
por: Lee, Hanseul, et al.
Publicado: (2022)

Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain
por: Parrella, Edoardo, et al.
Publicado: (2010)

A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity
por: El-Ami, Tayir, et al.
Publicado: (2014)

Human insulin/IGF-1 and familial longevity at middle age
por: Rozing, Maarten P., et al.
Publicado: (2009)

Central insulin‐like growth factor‐1 (IGF‐1) restores whole‐body insulin action in a model of age‐related insulin resistance and IGF‐1 decline
por: Huffman, Derek M., et al.
Publicado: (2015)

Crosstalk of protein clearance, inflammasome, and Ca(2+) channels in retinal pigment epithelium derived from age-related macular degeneration patients
por: Karema-Jokinen, Viivi, et al.
Publicado: (2023)

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
por: Hytti, Maria, et al.
Publicado: (2015)

Hydroquinone predisposes for retinal pigment epithelial (RPE) cell degeneration in inflammatory conditions
por: Bhattarai, Niina, et al.
Publicado: (2022)

Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the Insulin/IGF-1 Signalling Pathway
por: Meng, Fanhui, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9p6b633s6u1l36krmpt3qd08dr