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Augmented Liver Uptake of the Membrane Voltage Sensor Tetraphenylphosphonium Distinguishes Early Fibrosis in a Mouse Model
Mitochondrial (mito-) oxidative phosphorylation (OxPhos) is a critical determinant of cellular membrane potential/voltage. Dysregulation of OxPhos is a biochemical signature of advanced liver fibrosis. However, less is known about the net voltage of the liver in fibrosis. In this study, using the ra...
Autores principales: | Pandita, Himanshi, Mezey, Esteban, Ganapathy-Kanniappan, Shanmugasundaram |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573124/ https://www.ncbi.nlm.nih.gov/pubmed/34759830 http://dx.doi.org/10.3389/fphys.2021.676722 |
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