SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity

Transcribed CGG repeat expansions cause neurodegeneration in Fragile X‐associated tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA‐binding proteins (RBPs) into nuclear foci and undergo repeat‐associated non‐AUG (RAN) translation into toxic peptides. To identify proteins involved in thes...

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Detalles Bibliográficos
Autores principales: Malik, Indranil, Tseng, Yi‐Ju, Wright, Shannon E, Zheng, Kristina, Ramaiyer, Prithika, Green, Katelyn M, Todd, Peter K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573603/
https://www.ncbi.nlm.nih.gov/pubmed/34542927
http://dx.doi.org/10.15252/emmm.202114163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573603/
https://www.ncbi.nlm.nih.gov/pubmed/34542927
http://dx.doi.org/10.15252/emmm.202114163

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