Restoration of 5-methoxytryptophan protects against atherosclerotic chondrogenesis and calcification in ApoE(−/−) mice fed high fat diet

BACKGROUND: Toll-like receptor-2 (TLR2) promotes vascular smooth muscle cell (VSMC) transdifferentiation to chondrocytes and calcification in a p38 MAPK-dependent manner. Vascular 5-methoxytryptophan (5-MTP) is a newly identified factor with anti-inflammatory actions. As 5-MTP targets p38 MAPK for i...

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Detalles Bibliográficos
Autores principales: Lee, Guan-Lin, Liao, Tsai-Lien, Wu, Jing-Yiing, Wu, Kenneth K., Kuo, Cheng-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573875/
https://www.ncbi.nlm.nih.gov/pubmed/34749728
http://dx.doi.org/10.1186/s12929-021-00771-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573875/
https://www.ncbi.nlm.nih.gov/pubmed/34749728
http://dx.doi.org/10.1186/s12929-021-00771-1

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