PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells

BACKGROUND: Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding protein inducing dimerization with cytochrome P450, which mediates chemoresistance. Increased PGRMC1 expression is found in multiple types of resistant cancers, but the role of PGRMC1 in the ferroptosis of cancer cells...

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Detalles Bibliográficos
Autores principales: You, Ji Hyeon, Lee, Jaewang, Roh, Jong-Lyel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573965/
https://www.ncbi.nlm.nih.gov/pubmed/34749765
http://dx.doi.org/10.1186/s13046-021-02168-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573965/
https://www.ncbi.nlm.nih.gov/pubmed/34749765
http://dx.doi.org/10.1186/s13046-021-02168-2

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