Cargando…

PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells

BACKGROUND: Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding protein inducing dimerization with cytochrome P450, which mediates chemoresistance. Increased PGRMC1 expression is found in multiple types of resistant cancers, but the role of PGRMC1 in the ferroptosis of cancer cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	You, Ji Hyeon, Lee, Jaewang, Roh, Jong-Lyel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8573965/ https://www.ncbi.nlm.nih.gov/pubmed/34749765 http://dx.doi.org/10.1186/s13046-021-02168-2

Ejemplares similares

Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer
por: Lee, Jaewang, et al.
Publicado: (2020)

Poly(rC)-binding protein 1 represses ferritinophagy-mediated ferroptosis in head and neck cancer
por: Lee, Jaewang, et al.
Publicado: (2022)

Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis
por: Lee, Jaewang, et al.
Publicado: (2020)

Unleashing Ferroptosis in Human Cancers: Targeting Ferroptosis Suppressor Protein 1 for Overcoming Therapy Resistance
por: Lee, Jaewang, et al.
Publicado: (2023)

Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer
por: Shin, Daiha, et al.
Publicado: (2020)

Targeting Iron-Sulfur Clusters in Cancer: Opportunities and Challenges for Ferroptosis-Based Therapy
por: Lee, Jaewang, et al.
Publicado: (2023)

SLC7A11 as a Gateway of Metabolic Perturbation and Ferroptosis Vulnerability in Cancer
por: Lee, Jaewang, et al.
Publicado: (2022)

Use of a pre-vascularised oral mucosal cell sheet for promoting cutaneous burn wound healing
por: Lee, Jaewang, et al.
Publicado: (2018)

Development of an in vitro cell-sheet cancer model for chemotherapeutic screening
por: Lee, Jaewang, et al.
Publicado: (2018)

PGRMC1 and PGRMC2 in uterine physiology and disease
por: Pru, James K., et al.
Publicado: (2013)

PGRMC Proteins Are Coming of Age: A Special Issue on the Role of PGRMC1 and PGRMC2 in Metabolism and Cancer Biology
por: Cahill, Michael A., et al.
Publicado: (2021)

RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems
por: Shin, Daiha, et al.
Publicado: (2017)

Emerging Roles of Lipophagy in Cancer Metastasis
por: Yin, Haimeng, et al.
Publicado: (2022)

Accelerated oral wound healing using a pre-vascularized mucosal cell sheet
por: Lee, Jaewang, et al.
Publicado: (2017)

Retraction Note: Accelerated oral wound healing using a pre-vascularized mucosal cell sheet
por: Lee, Jaewang, et al.
Publicado: (2021)

Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway
por: Kim, Eun Hye, et al.
Publicado: (2017)

Progesterone Receptor Membrane Component (PGRMC)1 and PGRMC2 and Their Roles in Ovarian and Endometrial Cancer
por: Peluso, John J., et al.
Publicado: (2021)

Epitope mapping of anti-PGRMC1 antibodies reveals the non-conventional membrane topology of PGRMC1 on the cell surface
por: Kim, Ji Yea, et al.
Publicado: (2019)

Nrf2 inhibition reverses the resistance of cisplatin-resistant head and neck cancer cells to artesunate-induced ferroptosis
por: Roh, Jong-Lyel, et al.
Publicado: (2016)

Hypothalamic lipophagy and energetic balance
por: Singh, Rajat
Publicado: (2011)

A role for lipophagy in atherosclerosis
por: Laval, Thomas, et al.
Publicado: (2023)

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance
por: Kabe, Yasuaki, et al.
Publicado: (2016)

PGRMC1 Promotes Progestin-Dependent Proliferation of Breast Cancer Cells by Binding Prohibitins Resulting in Activation of ERα Signaling
por: Bai, Yingxue, et al.
Publicado: (2021)

The Role of Macrophage Lipophagy in Reverse Cholesterol Transport
por: Jeong, Se-Jin, et al.
Publicado: (2017)

Lipophagy: Connecting Autophagy and Lipid Metabolism
por: Singh, Rajat, et al.
Publicado: (2012)

Lipophagy and Alcohol-Induced Fatty Liver
por: Yang, Li, et al.
Publicado: (2019)

Lipolysis and lipophagy in lipid storage myopathies
por: Angelini, Corrado, et al.
Publicado: (2016)

Emerging Roles of Lipophagy in Health and Disease
por: Kounakis, Konstantinos, et al.
Publicado: (2019)

Pgrmc1 Knockout Impairs Oocyte Maturation in Zebrafish
por: Wu, Xin-Jun, et al.
Publicado: (2018)

UPR(ER) promotes lipophagy independent of chaperones to extend life span
por: Daniele, Joseph R., et al.
Publicado: (2020)

PGRMC2 is an Intracellular Heme Chaperone Critical for Adipocyte Function
por: Galmozzi, Andrea, et al.
Publicado: (2019)

PGRMC1: a new biomarker for the estrogen receptor in breast cancer
por: Craven, Rolf J
Publicado: (2008)

Comprehensive Analysis of the Implication of PGRMC1 in Triple-Negative Breast Cancer
por: Xu, Xin, et al.
Publicado: (2021)

Insights on the Role of PGRMC1 in Mitotic and Meiotic Cell Division
por: Lodde, Valentina, et al.
Publicado: (2022)

Active autophagy but not lipophagy in macrophages with defective lipolysis
por: Goeritzer, Madeleine, et al.
Publicado: (2015)

Lipophagy Impairment Is Associated With Disease Progression in NAFLD
por: Carotti, Simone, et al.
Publicado: (2020)

Lipophagy: Molecular Mechanisms and Implications in Metabolic Disorders
por: Shin, Dong Wook
Publicado: (2020)

The Expanding Role of Mitochondria, Autophagy and Lipophagy in Steroidogenesis
por: Bassi, Geetika, et al.
Publicado: (2021)

Alterations of Lipid Profile in Livers with Impaired Lipophagy
por: Jonas, Wenke, et al.
Publicado: (2022)

PGRMC1 Elevation in Multiple Cancers and Essential Role in Stem Cell Survival
por: Hampton, Kaia K., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rh8o30o4lfi8f707i0lti8lt2m