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TAD-like single-cell domain structures exist on both active and inactive X chromosomes and persist under epigenetic perturbations
BACKGROUND: Topologically associating domains (TADs) are important building blocks of three-dimensional genome architectures. The formation of TADs has been shown to depend on cohesin in a loop-extrusion mechanism. Recently, advances in an image-based spatial genomics technique known as chromatin tr...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574027/ https://www.ncbi.nlm.nih.gov/pubmed/34749781 http://dx.doi.org/10.1186/s13059-021-02523-8 |