Deep Parallel Characterization of AAV Tropism and AAV-Mediated Transcriptional Changes via Single-Cell RNA Sequencing

Engineered variants of recombinant adeno-associated viruses (rAAVs) are being developed rapidly to meet the need for gene-therapy delivery vehicles with particular cell-type and tissue tropisms. While high-throughput AAV engineering and selection methods have generated numerous variants, subsequent...

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Detalles Bibliográficos
Autores principales: Brown, David, Altermatt, Michael, Dobreva, Tatyana, Chen, Sisi, Wang, Alexander, Thomson, Matt, Gradinaru, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574206/
https://www.ncbi.nlm.nih.gov/pubmed/34759919
http://dx.doi.org/10.3389/fimmu.2021.730825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574206/
https://www.ncbi.nlm.nih.gov/pubmed/34759919
http://dx.doi.org/10.3389/fimmu.2021.730825

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