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PACAP–PAC1 Signaling Regulates Serotonin 2A Receptor Internalization

Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT(2A)) antagonism. Heterozygous Pacap mutant mice show a significantly higher hallucinogenic respo...

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Detalles Bibliográficos
Autores principales: Hayata-Takano, Atsuko, Shintani, Yusuke, Moriguchi, Keita, Encho, Naoki, Kitagawa, Kohei, Nakazawa, Takanobu, Hashimoto, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574227/
https://www.ncbi.nlm.nih.gov/pubmed/34759890
http://dx.doi.org/10.3389/fendo.2021.732456