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Anti-bias training for (sc)RNA-seq: experimental and computational approaches to improve precision

RNA-seq, including single cell RNA-seq (scRNA-seq), is plagued by insufficient sensitivity and lack of precision. As a result, the full potential of (sc)RNA-seq is limited. Major factors in this respect are the presence of global bias in most datasets, which affects detection and quantitation of RNA...

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Detalles Bibliográficos
Autores principales: Davies, Philip, Jones, Matt, Liu, Juntai, Hebenstreit, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574610/
https://www.ncbi.nlm.nih.gov/pubmed/33959753
http://dx.doi.org/10.1093/bib/bbab148