Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases

Cardiometabolic diseases are frequently polygenic in architecture, comprising a large number of risk alleles with small effects spread across the genome(1–3). Polygenic scores (PGS) aggregate these into a metric representing an individual’s genetic predisposition to disease. PGS have shown promise f...

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Detalles Bibliográficos
Autores principales: Ritchie, Scott C., Lambert, Samuel A., Arnold, Matthew, Teo, Shu Mei, Lim, Sol, Scepanovic, Petar, Marten, Jonathan, Zahid, Sohail, Chaffin, Mark, Liu, Yingying, Abraham, Gad, Ouwehand, Willem H., Roberts, David J., Watkins, Nicholas A., Drew, Brian G., Calkin, Anna C., Di Angelantonio, Emanuele, Soranzo, Nicole, Burgess, Stephen, Chapman, Michael, Kathiresan, Sekar, Khera, Amit V., Danesh, John, Butterworth, Adam S., Inouye, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574944/
https://www.ncbi.nlm.nih.gov/pubmed/34750571
http://dx.doi.org/10.1038/s42255-021-00478-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574944/
https://www.ncbi.nlm.nih.gov/pubmed/34750571
http://dx.doi.org/10.1038/s42255-021-00478-5

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