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Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases
Cardiometabolic diseases are frequently polygenic in architecture, comprising a large number of risk alleles with small effects spread across the genome(1–3). Polygenic scores (PGS) aggregate these into a metric representing an individual’s genetic predisposition to disease. PGS have shown promise f...
Autores principales: | Ritchie, Scott C., Lambert, Samuel A., Arnold, Matthew, Teo, Shu Mei, Lim, Sol, Scepanovic, Petar, Marten, Jonathan, Zahid, Sohail, Chaffin, Mark, Liu, Yingying, Abraham, Gad, Ouwehand, Willem H., Roberts, David J., Watkins, Nicholas A., Drew, Brian G., Calkin, Anna C., Di Angelantonio, Emanuele, Soranzo, Nicole, Burgess, Stephen, Chapman, Michael, Kathiresan, Sekar, Khera, Amit V., Danesh, John, Butterworth, Adam S., Inouye, Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8574944/ https://www.ncbi.nlm.nih.gov/pubmed/34750571 http://dx.doi.org/10.1038/s42255-021-00478-5 |
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