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Novel regulators of PrP(C) biosynthesis revealed by genome-wide RNA interference
The cellular prion protein PrP(C) is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrP(C) may represent therapeutic targets against human prion diseases. Here we performed an array...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575309/ https://www.ncbi.nlm.nih.gov/pubmed/34705895 http://dx.doi.org/10.1371/journal.ppat.1010013 |