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Novel regulators of PrP(C) biosynthesis revealed by genome-wide RNA interference

The cellular prion protein PrP(C) is necessary for prion replication, and its reduction greatly increases life expectancy in animal models of prion infection. Hence the factors controlling the levels of PrP(C) may represent therapeutic targets against human prion diseases. Here we performed an array...

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Detalles Bibliográficos
Autores principales:	Heinzer, Daniel, Avar, Merve, Pease, Daniel Patrick, Dhingra, Ashutosh, Yin, Jiang-An, Schaper, Elke, Doğançay, Berre, Emmenegger, Marc, Spinelli, Anna, Maggi, Kevin, Chincisan, Andra, Mead, Simon, Hornemann, Simone, Heutink, Peter, Aguzzi, Adriano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575309/ https://www.ncbi.nlm.nih.gov/pubmed/34705895 http://dx.doi.org/10.1371/journal.ppat.1010013

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