The role of TAp63γ and P53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cells

It has long been recognized that non-muscle-invasive bladder cancer (NMIBC) has a low propensity (20%) of becoming muscle-invasive (MIBC), and that MIBC carry many more p53 point mutations (p53m) than NMIBC (50% vs 10%). MIBC also has a higher mutation burden than NMIBC. These results suggest that D...

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Detalles Bibliográficos
Autores principales: Wang, Hsiang-Tsui, Lee, Hyun-Wook, Weng, Mao-wen, Liu, Yan, Huang, William C, Lepor, Herbert, Wu, Xue-Ru, Tang, Moon-shong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575459/
https://www.ncbi.nlm.nih.gov/pubmed/34747697
http://dx.doi.org/10.7554/eLife.71184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575459/
https://www.ncbi.nlm.nih.gov/pubmed/34747697
http://dx.doi.org/10.7554/eLife.71184

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