Pharmacokinetics of Monoclonal Antibody and Antibody Fragments in the Mouse Eye Following Systemic Administration

The ocular pharmacokinetics (PK) of antibody-based therapies are infrequently studied in mice due to the technical difficulties in working with the small murine eye. This study is the first of its kind to quantitatively measure the PK of variously sized proteins in the plasma, cornea/ICB, vitreous h...

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Detalles Bibliográficos
Autores principales: Bussing, David, Li, Zhe, Li, Yingyi, Chang, Hsuan-Ping, Chang, Hsueh-Yuan, Guo, Leiming, Verma, Ashwni, Shah, Dhaval K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575492/
https://www.ncbi.nlm.nih.gov/pubmed/34750690
http://dx.doi.org/10.1208/s12248-021-00647-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575492/
https://www.ncbi.nlm.nih.gov/pubmed/34750690
http://dx.doi.org/10.1208/s12248-021-00647-0

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