Deletion of Plasmodium falciparum ubc13 increases parasite sensitivity to the mutagen, methyl methanesulfonate and dihydroartemisinin

The inducible Di-Cre system was used to delete the putative ubiquitin-conjugating enzyme 13 gene (ubc13) of Plasmodium falciparum to study its role in ubiquitylation and the functional consequence during the parasite asexual blood stage. Deletion resulted in a significant reduction of parasite growt...

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Detalles Bibliográficos
Autores principales: Maneekesorn, Supawadee, Knuepfer, Ellen, Green, Judith L., Prommana, Parichat, Uthaipibull, Chairat, Srichairatanakool, Somdet, Holder, Anthony A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575778/
https://www.ncbi.nlm.nih.gov/pubmed/34750454
http://dx.doi.org/10.1038/s41598-021-01267-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575778/
https://www.ncbi.nlm.nih.gov/pubmed/34750454
http://dx.doi.org/10.1038/s41598-021-01267-6

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