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Enzymatic ligation of an antibody and arginine 9 peptide for efficient and cell-specific siRNA delivery

A fusion protein comprising an antibody and a cationic peptide, such as arginine-9 (R9), is a candidate molecule for efficient and cell-specific delivery of siRNA into cells in order to reduce the side effects of nucleic acid drugs. However, their expression in bacterial hosts, required for their de...

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Detalles Bibliográficos
Autores principales: Ando, Yu, Nakazawa, Hikaru, Miura, Daisuke, Otake, Maho, Umetsu, Mitsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575896/
https://www.ncbi.nlm.nih.gov/pubmed/34750461
http://dx.doi.org/10.1038/s41598-021-01331-1