Synaptic Zn(2+) potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior

Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn(2+)) also binds to the DAT, but the in vivo relevance of this interaction is unknown. We found that Zn(2+) concentrations in postmortem brain (caudate) tissue from humans who died of cocain...

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Detalles Bibliográficos
Autores principales: Gomez, Juan L., Bonaventura, Jordi, Keighron, Jacqueline, Wright, Kelsey M., Marable, Dondre L., Rodriguez, Lionel A., Lam, Sherry, Carlton, Meghan L., Ellis, Randall J., Jordan, Chloe J., Bi, Guo-hua, Solis, Oscar, Pignatelli, Marco, Bannon, Michael J., Xi, Zheng-Xiong, Tanda, Gianluigi, Michaelides, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575899/
https://www.ncbi.nlm.nih.gov/pubmed/34750356
http://dx.doi.org/10.1038/s41398-021-01693-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575899/
https://www.ncbi.nlm.nih.gov/pubmed/34750356
http://dx.doi.org/10.1038/s41398-021-01693-0

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