Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

PARP enzymes utilise NAD(+) as a co-substrate for their enzymatic activity. Inhibition of PARP1 is synthetic lethal with defects in either BRCA1 or BRCA2. In order to assess whether other genes implicated in NAD(+) metabolism were synthetic lethal with BRCA1 or BRCA2 gene defects, we carried out a g...

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Detalles Bibliográficos
Autores principales: Bajrami, Ilirjana, Walker, Callum, Krastev, Dragomir B., Weekes, Daniel, Song, Feifei, Wicks, Andrew J., Alexander, John, Haider, Syed, Brough, Rachel, Pettitt, Stephen J., Tutt, Andrew N. J., Lord, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575930/
https://www.ncbi.nlm.nih.gov/pubmed/34750509
http://dx.doi.org/10.1038/s42003-021-02770-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575930/
https://www.ncbi.nlm.nih.gov/pubmed/34750509
http://dx.doi.org/10.1038/s42003-021-02770-2

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