Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein

During biosynthesis, proteins can begin folding co-translationally to acquire their biologically-active structures. Folding, however, is an imperfect process and in many cases misfolding results in disease. Less is understood of how misfolding begins during biosynthesis. The human protein, alpha-1-a...

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Detalles Bibliográficos
Autores principales: Plessa, Elena, Chu, Lien P., Chan, Sammy H. S., Thomas, Oliver L., Cassaignau, Anaïs M. E., Waudby, Christopher A., Christodoulou, John, Cabrita, Lisa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576036/
https://www.ncbi.nlm.nih.gov/pubmed/34750347
http://dx.doi.org/10.1038/s41467-021-26531-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576036/
https://www.ncbi.nlm.nih.gov/pubmed/34750347
http://dx.doi.org/10.1038/s41467-021-26531-1

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