Cargando…
Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein
During biosynthesis, proteins can begin folding co-translationally to acquire their biologically-active structures. Folding, however, is an imperfect process and in many cases misfolding results in disease. Less is understood of how misfolding begins during biosynthesis. The human protein, alpha-1-a...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576036/ https://www.ncbi.nlm.nih.gov/pubmed/34750347 http://dx.doi.org/10.1038/s41467-021-26531-1 |