Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors

In contrast to the processes controlling the complexation, targeting and uptake of polycationic gene delivery vectors, the molecular mechanisms regulating their cytoplasmic dissociation remains poorly understood. Upon cytosolic entry, vectors become exposed to a complex, concentrated mixture of mole...

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Detalles Bibliográficos
Autores principales: Raynold, Aji Alex M., Li, Danyang, Chang, Lan, Gautrot, Julien E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576037/
https://www.ncbi.nlm.nih.gov/pubmed/34750370
http://dx.doi.org/10.1038/s41467-021-26695-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576037/
https://www.ncbi.nlm.nih.gov/pubmed/34750370
http://dx.doi.org/10.1038/s41467-021-26695-w

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