An Industrial Procedure for Pharmacodynamic Improvement of Metformin HCl via Granulation with Its Paracellular Pathway Enhancer Using Factorial Experimental Design

BACKGROUND: Sorbitan monostearate is a surfactant used in the food industry. It was proved as a penetration enhancer to metformin HCl via a paracellular pathway. It is solid at room temperature and has a low melting point. Therefore, it was selected, as a granulating agent for metformin HCl. METHODS...

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Detalles Bibliográficos
Autores principales: Mady, Omar Y, Al-Shoubki, Adam A, Donia, Ahmed A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576103/
https://www.ncbi.nlm.nih.gov/pubmed/34764634
http://dx.doi.org/10.2147/DDDT.S328262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576103/
https://www.ncbi.nlm.nih.gov/pubmed/34764634
http://dx.doi.org/10.2147/DDDT.S328262

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