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Syndecan-1 Shedding by Matrix Metalloproteinase-9 Signaling Regulates Alveolar Epithelial Tight Junction in Lipopolysaccharide-Induced Early Acute Lung Injury

INTRODUCTION: Alveolar epithelial tight junction damage and glycocalyx syndecan-1 (SDC-1) degrading are key factors to pulmonary edema of acute lung injury (ALI). Matrix metalloproteinase-9 (MMP-9) was involved in glycocalyx shedding, which was vital in SDC-1 degrading. This study aimed to investiga...

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Detalles Bibliográficos
Autores principales: Zhang, Dong, Zhang, Jin-tao, Pan, Yun, Liu, Xiao-fei, Xu, Jia-wei, Cui, Wen-jing, Qiao, Xin-rui, Dong, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576260/
https://www.ncbi.nlm.nih.gov/pubmed/34764672
http://dx.doi.org/10.2147/JIR.S331020